diseases of female reproductive apparatus (see also physiology of female reproductive apparatus); diseases of breast / mastopathies (see also physiology of breast); athelia: congenital absence of the nipple(s)
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. evoked twitch response to the mouse vas deferens, a characteristic effect of.
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Cb1 Receptor Mechanism Definition Abstract Mammalian tissues express at least two types of cannabinoid receptor, CB1 and CB2, both G. to Gs. Additional signalling mechanisms for cannabinoid CB1 and CB2 receptors have been proposed. Examples of Ki values of certain cannabinoid CB1 and/or CB2 receptor agonists for the in vitro displacement of. Photo by Lauri Andler. I’ve been asked
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The nonpsychoactive plant cannabinoid, (−)-cannabidiol, modulates in vivo responses to Δ 9-tetrahydrocannabinol.We have found that cannabidiol can also interact with cannabinoid CB 1 receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB 1 receptors mediate inhibition of electrically evoked contractions.
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You have free access to this content Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens
Our findings validate the use of the rat vas deferens as a viable bioassay for cannabinoid receptor activity and suggest an optimized method for the analysis of agonist-antagonist interactions under conditions of endogenous agonist tone. Preliminary accounts of these data have been published in abstract form (Lay et al.,
E-mail: [email protected] The unequivocal demonstration that mammalian tissues express cannabinoid receptors was followed by the discovery that they can also produce endogenous ligands for these receptors. 10 These.
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The contractile response of the guinea pig vas deferens to motor nerve stimulation is biphasic. The first phase is.
In the present study, the effects of anandamide and WIN 55,212-2, cannabinoid receptor agonists, were investigated on electrical field stimulation (EFS)-induced biphasic twitch responses obtained from the epididymal and prostatic portions of rabbit vas deferens strips. 2. Anandamide and WIN 55,212-2 dose-dependently.
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Here we show that genetic or pharmacologic silencing of cannabinoid receptor CB1 causes retention of a large number of embryos in the mouse oviduct, eventually leading to pregnancy failure. This is reversed by isoproterenol, a.
types of non-cannabinoid receptor. Consequently, to establish whether or not the production of such inhibition by a test compound is CB1 receptor-mediated, it is necessary to measure the susceptibility of this compound to antagonism by a selective CB1 antagonist. For the mouse vas deferens, an alternative strategy.
Learn about potential effects of different cannabinoids derived from plants.
How to Cite. Barun, S., Vural, I. M., Dileköz, E., Ercan, Z. S. and Sarioglu, Y. (2005), EFFECTS OF CANNABINOID RECEPTOR ACTIVATION ON RABBIT BISECTED VAS DEFERENS STRIPS.
The nonpsychoactive plant cannabinoid, (-)-cannabidiol, modulates in vivo responses to Delta(9)-tetrahydrocannabinol. We have found that cannabidiol can also interact with cannabinoid CB(1) receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB(1) receptors.